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KMID : 0614619930250050997
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Korean Journal of Gastroenterology
1993 Volume.25 No. 5 p.997 ~ p.1003
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Transmission Electron Microscopic Findings of the Intra-Hepatic Biliary Tract after Bile Duct Ligation in Rats
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Abstract
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Alteration of bile canalicular structure are known to occur in both intra-and extrahepatic cholestasis that develop in men as well as experimental animals.
In order to evaluate the biochemical and ultrastructural characteristics of cholestasis in the liver of the rats. The authors conducted liver function test and examined the fine structural changes of intrahepatic biliary tract both in normal
state
and
after 4 different time periods of common bile ducts ligation with the transmission electron microscope.
The serum SGPT began to rise immediately after the common bile duct ligation, showing highest value in the 24 hours group and the value decreased thereafter. The total bilirubin. Total cholesterol, γ-CTP and alkaline phosphatase began to rise
rapidly
after the common bile duct ligation. Showing highest values in the 1 week experimental group and the values decreased thereafter.
After the common bile duct ligation, changes of the liver were most prominent in the bile canaliculiwhich showed typical structural alterations. There was the progressive dilatation of bile canaliculi with the loss of microvilli sometimes forming
sacculation and diverticulation.
Prominent ultrastructural changes of bile ductules after bile duct ligation were persistent bleb formations and decreased number of microvilli of luminal surface of ductular epithelial cells. The ductular epithelium showed strophic changes and
widening
of intercelldlar space with abnornial microvilli was also observed.
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